The objective of this study was to identify disrupted pathways in teratozoospermia by systematically tracking dysregulated modules in reweighted protein-protein interaction (PPI) networks. We inferred and reweighted the PPI networks of normal and teratozoospermia groups based on Spearman correlation coefficients. Modules in the PPI networks were explored via a clique-merging algorithm and alter...

INTRODUCTION Defective sperm quality is a significant cause of infertility. It is known that cigarette smoking affects semen quality. Our aim was to compare the semen of infertile cigarette smokers with infertile non-smokers to study the effect of smoking on semen quality. METHODS Semen samples of 100 cigarette smokers and 100 strictly non-smoking primary infertility patients were included in...

Background: This study was aimed to see the frequency of polyzoospermia and teratozoospermia, among men with history of infertility, presenting at National Institute of Health, Islamabad. Material and Methods: Seven hundred and ninety married men presenting with a complaint of infertility underwent their semen analysis. They were categorized on the basis of sperm count and morphology. The sperm...

Obesity impairs male fertility, providing evidence for a link between adipose tissue and reproductive function; however, potential consequences of adipose tissue paucity on fertility remain unknown. Lack of s.c. fat is a hallmark of Berardinelli-Seip congenital lipodystrophy type 2 (BSCL2), which is caused by mutations in BSCL2-encoding seipin. Mice with a targeted deletion of murine seipin mod...

s:1750:"Background: We propose in this work to assess the effect of total and severe teratozoospermia on the outcome of intra cytoplasmic sperm injection( ICSI) essentially the biological side and try to highlight the factor in the success or failure of the attempt in cases of extreme or total teratozoospermia. Materials and Methods: This is a comparative retrospective study including 140 coupl...

Parathion is an organophosphorate pesticide amply used in agriculture. Many alterations induced by organophosphorate pesticides have been described, such as: cytogenetic alterations in germinal cells, oligozoospermia and teratozoospermia in the mouse. The effect of Parathion, both pure (PP) and commercial (PC), on mouse interstitial cell testosterone production was evaluated in vivo and in vitr...

Klinefelter syndrome and Y-chromosomal microdeletion analyses were once the only two genetic tests offered to infertile men. Analyses of aurora kinase C (AURKC) and DPY19L2 are now recommended for patients presenting macrozoospermia and globozoospermia, respectively, two rare forms of teratozoospermia particularly frequent among North African men. We carried out genetic analyses on Algerian pat...